Prevalence of oral HPV among people living with HIV (PLHIV) in Pune, India

Background: People living with HIV (PLHIV) are at an increased risk of human papillomavirus (HPV)-related head and neck cancers (HNCs). However, there is little data on the prevalence oral HPV among PLHIV in India, limiting planning preventive strategies. Methods: We used cross-sectional from cancer screening study conducted at the antiretroviral therapy (ART) centre of Byramjee-Jeejeebhoy Government Medical College-Sassoon General Hospitals (BJGMC-SGH). ≥21 years age no prior history HNCs were enrolled. We determined high-risk oncogenic (hrHPV) low-risk non-oncogenic (lrHPV) using real-time PCR Next-Generation Sequencing. used multinomial logistic regression to determine ratios (PRs) different sociodemographic, clinical, behavioural predictors hrHPV lrHPV. Multivariable models adjusted for age, sex, CD4 count duration ART. Results: Of 582 enrolled, median was 40 (IQR: 34–46) 54% male. More than a fourth (25.8%) had multiple sexual partners 11% given sex. Median counts 510 cells/mm3 338–700). The 4.5% lrHPV 3.4%. Of those hrHPV, 77% HPV16. There significant associations any both analyses. Conclusions: found (hrHPV lrHPV) be 7.9% India. Larger studies required better understand factors Indian PLHIV.